The Lancet Vol. 358; pages 711-717, September 1, 2001 Cancer in siblings of children with cancer in the Nordic countries: A population-based cohort study Jeanette Falck Winther, Risto Sankila, John D Boice Jr, Hrafn Tulinius, Andrea Bautz, Lotti Barlow, Eystein Glattre, Froydis Langmark, Torgil R Moller, John Mulvihill, Gudridur H Olafsdottir, Annukka Ritvanen, Jorgen H Olsenet Introduction Relevance: In some inherited childhood cancers there is an increased risk of children and their siblings getting cancer. Hypothesis: By studying the relationship between children with cancer and genetic heredity and by evaluating the influence of recessive cancer causing conditions, the study hoped to determine that children whose siblings have common types of cancer are not at an increased risk of getting cancer themselves Experimental Design Forty two thousand two hundred and seventy-seven siblings, from 5 Scandinavian countries (Denmark, Finland, Iceland, Norway and Sweden) of 25,605 children with cancer were selected by accessing linkage records and cancer registries of surviving children and adolescents with cancer. Fourteen thousand childhood cancer survivors were compared with the expected number of cancers among children in the general population. Excluded from the study were 56 families with cancer linked genes, adopted and half-siblings. The index patient in the family was the child with the earliest diagnosis date of cancer. The siblings were all younger than 20 years old from 1943 in Denmark, 1953 in Finland and Norway, 1954 in Iceland, and 1958 in Sweden. They analyzed the relationships between specific childhood cancers and the risks of cancer in a family from a large population for 40 years. Follow up ended at the time of death or if the subject emigrated, or December 31, 1994, which ever came first (except for Norway which ended i…
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